5/12/2023 0 Comments Overgrowth free download alpha 191The prevalence of DIGO in CCB and non-CCB was the same (49.5%). Results: Amlodipine was the most commonly used CCB. Statistical significance was set at P < 0.05. Continuous and nominal variables were described with means, standard deviations and frequencies. GO was assessed using New Clinical Index for DIGO and data was analyzed with SPSS version 21 (Armonk, NY: IBM Corp). Interviewer-administered questionnaires was used to obtain socio-demographic information as well as medical and drug history. Methodology: 170 hypertensive patients were recruited for the study 85 calcium channel blocker (CCB) and 85 non-CCB users. Drug Induced Gingival Overgrowth (DIGO) occurs within 3 months of treatment and is more prevalent in younger age group with predilection for the anterior gingival tissue and usually not associated with attachment loss or tooth mobility unless there is an existing periodontal disease. Conclusion: This data indicates the level of salivary IgA was significantly affected in patients with DIGE which may compromise the defense mechanism of saliva.īackground: Gingival overgrowth may be idiopathic or secondary. The salivary IgA level was significantly decreased (p=0.03) among hypertensive patients with DIGE compared to those without DIGE. Twenty-one (44.7%) patients presented with DIGE. Amlodipine was found to be the most common (55.3%) antihypertensive drug consumed. Results: Eighty-three percent and 17.0% of hypertensive patients were on CCBs and non-CCBs respectively. The p-value of less than 0.05 at a 95% confidence interval is considered statistically significant. Data was analyzed using SPSS version 26.0. Twenty-one (44.7%) males and 26 (55.3%) females had participated in this study. Methods: This cross-sectional study comprised 47 hypertensive patients who had consumed antihypertensive drugs for at least 3 months. Objective: This study aimed to determine the association of salivary IgA level with DIGE. Immunoglobulin A (IgA) in saliva which involves in defense mechanism was shown to be affected in patients with DIGE. Immune response alteration is one of the proposed mechanisms for DIGE. Drug-influenced gingival enlargement (DIGE) among hypertensive patients is commonly associated with antihypertensive drugs such as calcium channel blockers (CCBs).
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